Shell script to edit a file

Hello,
I have a big file in wich I would like to rename inside this exactly the string '_ME' and not rename in case we have 'ABC_MELANGE'. Is there a way to do it by using a shell script?
Any tip will be apreciated.

The file is like described bellow, after using command more filename :

toto test@GR_4||4_35_1_ME||4_35_17
DntowoB.nts
toto test@DT_3||4_35_1_ME||4_35_17
DntsGoF.nts
toto test@FAIFAI11-O8M5_south_e9000/A18_06_MEmCentralNW_PAB/07
DnBs0I2.nts
toto test@FAIFAITulipa-M6C-1010/A18_06_MEmCentral_PAB/07
Dot50nD.nts
toto test@GR_2||4_55_1_ME||4_55_17
Dp2GzpT.nts
toto test@DT_2||4_55_1_ME||4_55_17
Dp2JIpX.nts
toto test@RDEEP_2||ABC_MELANGE-3B_ME||ABC_MELANGE-3B_Leg17
Dr1aFqf.nts
toto test@NPHI_2||ABC_MELANGE-3B_ME||ABC_MELANGE-3B_Leg17
Dr1e7qj.nts
toto test@GR_2||ABC_MELANGE-3B_ME||ABC_MELANGE-3B_Leg17
Dr1hBqn.nts
toto test@DT_2||ABC_MELANGE-3B_ME||ABC_MELANGE-3B_Leg17
Dr1lUqr.nts
toto test@RHOB_3||ABC_MELANGE-3B_ME||ABC_MELANGE-3B_Leg17
Dr1pEqv.nts

Thanks in advance

Taking a guess not having a desired output....

sed 's#_ME|#_newME|#g' myFile
awk -F \| '{if ($3~/_ME$/ {DO the rename job} }' infile

Hi vgersh99,
thank you for your help. It works perfectly.