Search and replace only the first occurance

Hi,

I need to search a string and replace with nothing, but only the First occurring string

using sed/perl/awk

its simple .. wats your try ..

tried this, but didn't work

sed 's/\(.*\)'$line'/\1/' $file_cases > $file_temp_cases_tmp

also tried

sed 's/string/replace/' filename

but it replaces all the string

with slight modification ..

$ sed 's/string/replace/1' filename