Remove lines in file1 with values from file2

Hello,
I have two data files:

file1

12345 aa bbb cccc
98765 qq www uuuu
76543 pp rrr bbbbb
34567 nn ccc sssss
87654 qq ppp rrrrr

file2

98765
34567

I need to remove the lines from file1 if the first field contains a value that appears in file2:

output

12345 aa bbb cccc
76543 pp rrr bib
87654 qq ppp rrrrr

Thanks so much!

Checkout the below thread. I too had a same requirement.

Perfect, thanks!