Reference data check for delete

Dear All,

I have a master file - Master.txt
100|ABC
200|CED
500|XYZ
800|POL

I have a reference file - Ref.txt
200
800

What is desired..
Check for all those records in reference file matching with those within master file and then delete those records from Master file

So, at end, Master file shud look like below
100|ABC
500|XYZ
800|POL

Please advice, possible options, to achieve this

Regards,
Suresh

use grep

grep -v -f Ref.txt Master.txt