Compare 2 Large files

Hi,
i want to compare 2 large files both around 300 mb. They are text files having only one column of numbers. I wish to get the unique values in file2. I tried using diff but it gave an error of memory exhausted. Both files are sorted and i am running on a 1gb ram core 2 duo 2ghz. Help!!
Thanks in advance
AC

grep -f file1 file2

hey zaxxon it wont check for line by line i hope like comparing 1st line of file1 and 1st file of line2

diff -y file file2

::EDIT:: disregard this post I mislooked your post. Might try the solution of zaxxon with the -v switch.

grep is also taking up a lot of time and memory