I have a headless remote Mini in which I was hoping to reduce bandwidth consumption by following an Apple knowledge base note (Mac OS X v10.6: Disabling mDNSResponder will disable DNS) which is a method to stop Bonjour service advertisement.
Now I can't connect to the Mini via SSH, screen sharing, sftp, smtp or anything else. I know the Mini is alive, I can ping/traceroute it.
I took the mini to the Genius Bar and after confirming that the hard drive was ok, they reinstalled the OS and all seems ok now. I was then able to disable Bonjour service advertising again without any problems.
I have no idea what happened but I suspect when I rebooted after the first attempt at shutting off advertising some critical boot file got damaged.