multitude of packets from 127.0.0.1

I was checking routing table, and noticed that our server has a lot packets from localhost:

Routing Table: IPv4
  Destination           Gateway           Flags  Ref   Use   Interface
-------------------- -------------------- ----- ----- ------ ---------
..
127.0.0.1            127.0.0.1            UH       4713304405  lo0
..

should we worry about it? other servers have small values for 'use',
but we do use ftp regularly on this one.

Lots of things can cause that - example: Suppose your box name is 'waffle', and there is software running on it that opens AF_INET sockets that connect to nodename waffle or localhost. That would cause what you see.

If your sytem has been up more than a few days and if you are not having problems it is likely not worth trying to find the source.

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