1 VPS with 2 IP addresses. How to make them independent?

Applications IP Networking
1

I have this in /etc/network/interfaces:

auto ens3
 iface ens3 inet static
          address 46.xx.xxx.1x7
         netmask 255.255.252.0
         broadcast 46.38.xxx.255
         gateway 46.xx.xxx.1  

auto ens3:0 
iface ens3:0 inet static
      address 188.xx.xx.xx5     
      netmask 255.255.255.255

I want the interfaces of my VPS to be independent.
Without the traffic of ens3:0 interface pass by ens3 interface.
It's possible?